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Article

Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex

19 May 2016

Abstract excerpt

Artemis is a vertebrate nuclease with both endo- and exonuclease activities that acts on a wide range of nucleic acid substrates. It is the main nuclease in the non-homologous DNA end-joining pathway (NHEJ). Not only is Artemis important for the repair of DNA double-strand breaks (DSBs) in NHEJ, it is essential in opening the DNA hairpin intermediates that are formed during V(D)J recombination. Thus, humans with...

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PMID: 27198222
DOI: 10.1093/nar/gkw456

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