Establishment of a standardized system to perform population structure analyses with limited sample size or with different sets of SNP genotypes.

Abstract excerpt

Recent studies have demonstrated that principal component analysis (PCA) can detect the presence of population mixture and admixture in a sample and thus can be used to correct population stratification in genome-wide association studies (GWAS). We propose a complementary approach to PCA that compensates for potential weaknesses associated with PCA, so that one can perform population structure analyses using...

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