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Article

A small molecule-directed approach to control protein localization and function.

Yeast (Chichester, England) - 1 Aug 2008

Geda Prasanthi, Patury Srikanth, Ma Jun, Bharucha Nike, Dobry Craig J, Lawson Sarah K, Gestwicki Jason E, Kumar Anuj

Abstract excerpt

Protein localization is tightly linked with function, such that the subcellular distribution of a protein serves as an important control point regulating activity. Exploiting this regulatory mechanism, we present here a general approach by which protein location, and hence function, may be controlled on demand in the budding yeast. In this system a small molecule, rapamycin, is used to temporarily recruit a...

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PMID: 18668531
DOI: 10.1002/yea.1610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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