Article
Genetic and environmental influences on therapeutic and toxicity outcomes: studies with CYP2A6.
Current clinical pharmacology - 1 Sept 2006
Satarug Soisungwan, Tassaneeyakul Wichittra, Na-Bangchang Kesara, Cashman John R, Moore Michael R
Abstract excerpt
The idea that the liver enzyme cytochrome P450 2A6 (CYP2A6), known also as nicotine C-oxidase, is one of the determinants of smoking addiction and smoking behavior is primarily based on its role in nicotine metabolism and disposition. The results of studies linking the CYP2A6 genetic polymorphism with smoking dependence and smoking behavior however remain controversial. The most likely causes of the controversies...
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