Article
Haplotype structure and allele frequencies of CYP2B6 in a Korean population.
Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2004
Cho Joo-Youn, Lim Hyeong-Seok, Chung Jae-Yong, Yu Kyung-Sang, Kim Jung-Ryul, Shin Sang-Goo, Jang In-Jin
Abstract excerpt
Cytochrome P450 2B6 (CYP2B6) metabolizes a number of therapeutic drugs and its metabolic activity varies markedly in human liver. Although genetic polymorphisms of CYP2B6 have been reported in noncoding and coding regions, little information is available regarding single nucleotide polymorphisms (SNPs) and their haplotypes in noncoding regions in Asians. Fourteen previously reported SNPs were determined by...
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