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Article

The 9-1-1 DNA clamp is required for immunoglobulin gene conversion.

Molecular and cellular biology - 1 Oct 2008

Saberi Alihossein, Nakahara Makoto, Sale Julian E, Kikuchi Koji, Arakawa Hiroshi, Buerstedde Jean-Marie, Yamamoto Kenichi, Takeda Shunichi, Sonoda Eiichiro

Abstract excerpt

Chicken DT40 cells deficient in the 9-1-1 checkpoint clamp exhibit hypersensitivity to a variety of DNA-damaging agents. Although recent work suggests that, in addition to its role in checkpoint activation, this complex may play a role in homologous recombination and translesion synthesis, the cause of this hypersensitivity has not been studied thoroughly. The immunoglobulin locus of DT40 cells allows monitoring...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 18662998
DOI: 10.1128/MCB.00156-08
PMCID: PMC2547007

Genes

RAD17
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The 9-1-1 DNA clamp is required for immunoglobulin gene conversion.PMID 18662998Read ↗

Reduced X-ray resistance and homologous recombination frequencies in a RAD54-/- mutant of the chicken DT40 cell line.Semantic proximity Read ↗

Brca1 in immunoglobulin gene conversion and somatic hypermutation.Semantic proximity Read ↗

Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.Semantic proximity Read ↗

The Rad51 paralog Rad51B promotes homologous recombinational repair.Semantic proximity Read ↗

Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation.Semantic proximity Read ↗

UBE2V2 (MMS2) is not required for effective immunoglobulin gene conversion or DNA damage tolerance in DT40.Semantic proximity Read ↗

DNA polymerases nu and theta are required for efficient immunoglobulin V gene diversification in chicken.Semantic proximity Read ↗

Similar effects of Brca2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination.Semantic proximity Read ↗

Multiple roles of vertebrate REV genes in DNA repair and recombination.Semantic proximity Read ↗

The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae.Semantic proximity Read ↗

Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1.Semantic proximity Read ↗

Immunoglobulin gene conversion in chicken DT40 cells largely proceeds through an abasic site intermediate generated by excision of the uracil produced by AID‐mediated deoxycytidine deaminationSemantic proximity Read ↗

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