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Article

When the genome plays dice: circumvention of the spindle assembly checkpoint and near-random chromosome segregation in multipolar cancer cell mitoses.

PloS one - 2 Apr 2008

Gisselsson David, Håkanson Ulf, Stoller Patrick, Marti Dominik, Jin Yuesheng, Rosengren Anders H, Stewénius Ylva, Kahl Fredrik, Panagopoulos Ioannis

Abstract excerpt

BACKGROUND: Normal cell division is coordinated by a bipolar mitotic spindle, ensuring symmetrical segregation of chromosomes. Cancer cells, however, occasionally divide into three or more directions. Such multipolar mitoses have been proposed to generate genetic diversity and thereby contribute to clonal evolution. However, this notion has been little validated experimentally. PRINCIPAL FINDINGS: Chromosome...

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Identifiers

PMID: 18392149
DOI: 10.1371/journal.pone.0001871
PMCID: PMC2289843

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AURKB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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