Article
Mutations of phosphorylation sites Ser10 and Thr187 of p27Kip1 abolish cytoplasmic redistribution but do not abrogate G0/1 phase arrest in the HepG2 cell line.
Biochemical and biophysical research communications - 1 Sept 2006
Guan Xiaoxiang, Chen Longbang, Wang Jinghua, Geng Huaicheng, Chu Xiaoyuan, Zhang Qun, Du Lili, De Wei
Abstract excerpt
The cyclin-dependent kinase (CDK) inhibitor p27(Kip1) is an important regulator of cell cycle progression as it negatively regulates G(0/1) progression and plays a major role in controlling the cell cycle. The screening of the p27(Kip1) sequence identified many potential phosphorylation sites. Although Ser(10) and Thr(187) were shown to be important for p27(Kip1) function, the effects of a combined deletion of...
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