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Article

p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis.

Oncogene - 21 Jun 2001

Yang H Y, Shao R, Hung M C, Lee M H

Abstract excerpt

HER2/neu, a receptor tyrosine kinase oncogene, promotes mitogenic growth and transformation of cancer cells. We previously identified that its oncogenic signals down-regulate the cyclin-dependent kinase inhibitor p27 Kip1, which is defined as a haplo-insufficient tumor suppressor. Here, we applied the human p27 gene as a novel anticancer agent for HER2/neu-overexpressing cells under the control of a tetracycline...

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Source

Identifiers

PMID: 11439332
DOI: 10.1038/sj.onc.1204472

Genes

CDK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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