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Article

Significant association of MTHFD1 1958G>A single nucleotide polymorphism with nonsyndromic cleft lip and palate in Indian population.

Medicina oral, patologia oral y cirugia bucal - 1 Nov 2014

Murthy Jyotsna, Gurramkonda Venkatesh-Babu, Lakkakula Bhaskar V K S

Abstract excerpt

OBJECTIVE: Nonsyndromic cleft lip and palate (NSCLP) is genetically distinct from those with syndromic clefts, and accounts for ~70% of cases with Oral clefts. Folate, or vitamin B9, is an essential nutrient in our diet. Allelic variants in genes involved in the folate pathway might be expected to have an impact on risk of oral clefts. Given the key role of methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) in...

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Identifiers

PMID: 25129243
DOI: 10.4317/medoral.19796
PMCID: PMC4259380

Genes

MTHFD1

Provenance

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