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Article

PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1.

EMBO reports - 1 Sept 2008

Jonas Mary Cabell, Costantini Claudio, Puglielli Luigi

Abstract excerpt

We have recently identified a new form of post-translational regulation of BACE1 (beta-site amyloid precursor protein (APP)-cleaving enzyme 1), a membrane protein that acts as the rate-limiting enzyme in the generation of the Alzheimer disease amyloid beta-peptide (Abeta). Specifically, BACE1 is transiently acetylated on seven lysine residues in the lumen of the endoplasmic reticulum/endoplasmic reticulum-Golgi...

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Source

Open in PubMed Open full text

Identifiers

PMID: 18660751
DOI: 10.1038/embor.2008.132
PMCID: PMC2529349

Genes

BACE1
PCSK9
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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