Article

Deficient ER Acetyl-CoA Import in Acinar Cells Leads to Chronic Pancreatitis

2020-03-26

Abstract excerpt

Maintaining endoplasmic reticulum (ER) proteostasis is essential for pancreatic acinar cell function. Under conditions of severe ER stress, activation of pathogenic unfolded protein response pathways play a central role in the development and progression of pancreatitis. A key event in this pathogenic response is a loss of the transcription factor spliced XBP1 (XBP1s) and activation of the PERK pathway. Less is kn...

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Literature Corpus work: 53cdf220-42e7-5c02-a78e-d7547e2b6187
DOI: 10.1101/2020.03.25.008557

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