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Article

Evidence for dimeric BACE-mediated APP processing.

Biochemical and biophysical research communications - 26 Feb 2010

Jin Shaobo, Agerman Karin, Kolmodin Karin, Gustafsson Elin, Dahlqvist Camilla, Jureus Anders, Liu Gang, Fälting Johanna, Berg Stefan, Lundkvist Johan, Lendahl Urban

Abstract excerpt

beta-Secretase (BACE) is an aspartyl protease, which proteolytically processes amyloid precursor protein, making BACE an interesting pharmacological target in Alzheimer's disease. To study the enzymatic function of BACE, we mutated either of the two aspartic acid residues in the active site of BA...

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Source

Identifiers

PMID: 20097169
DOI: 10.1016/j.bbrc.2010.01.064

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20097169-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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