Molecular analysis of the Ink4a/Rb1-Arf/Tp53 pathways in radon-induced rat lung tumors.

doi:10.1016/j.lungcan.2008.06.007

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Article

Molecular analysis of the Ink4a/Rb1-Arf/Tp53 pathways in radon-induced rat lung tumors.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2009

Bastide Kristell, Guilly Marie-Noëlle, Bernaudin Jean-François, Joubert Christophe, Lectard Bruno, Levalois Céline, Malfoy Bernard, Chevillard Sylvie

Abstract excerpt

Inhalation of radon is closely associated with an increased risk of lung cancers. While the involvement of Ink4a in lung tumor development has been widely described, the tumor suppressor gene has not been studied in radon-induced lung tumors. In this study, loss of heterozygosity (LOH) analysis of the Cdkn2a locus, common to the Ink4a and Arf genes, was performed on 33 radon-induced rat lung tumors and showed a...

Topics

Animals
Carcinogens, Environmental
Cyclin-Dependent Kinase Inhibitor p16
DNA Methylation
Gene Expression Regulation, Neoplastic
Immunohistochemistry
Lung Neoplasms
Mutation
Neoplasms, Experimental
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Neoplasm

Radon

Rats

Rats, Inbred F344

Rats, Inbred WF

Rats, Sprague-Dawley

Retinoblastoma Protein

Tumor Suppressor Protein p14ARF

Source

Open in PubMed

Identifiers

PMID: 18656278
DOI: 10.1016/j.lungcan.2008.06.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18656278-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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