Article
Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation.
Genes and immunity - 1 Oct 2008
Adarichev V A, Vegvari A, Szabo Z, Kis-Toth K, Mikecz K, Glant T T
Abstract excerpt
Proteoglycan (PG)-induced arthritis (PGIA) is an autoimmune inflammatory disease controlled by multiple genes in the murine genome. BALB/c x DBA/2 congenic strains carrying four major PGIA chromosome loci were immunized, and positions of loci on chromosomes 3, 7, 8 and 19 (loci Pgia26, Pgia21, Pgia4 and Pgia12, respectively) were confirmed. Each congenic strain exhibited a different pattern of regulation of...
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