Article
Sex effect on clinical and immunologic quantitative trait loci in a murine model of rheumatoid arthritis.
Arthritis and rheumatism - 1 Jun 2003
Adarichev Vyacheslav A, Nesterovitch Andrew B, Bárdos Tamás, Biesczat Darci, Chandrasekaran Raman, Vermes Csaba, Mikecz Katalin, Finnegan Alison, Glant Tibor T
Abstract excerpt
OBJECTIVE: To explore the effect of sex on clinical and immunologic traits in major histocompatibility complex-matched (H-2d) F(2) hybrid mice with proteoglycan (PG)-induced arthritis and to identify how the quantitative trait locus (QTL) on the X chromosome influences the onset QTL of another chromosome. METHODS: (BALB/c x DBA/2)F(2) hybrid mice were immunized with cartilage PG, and a genome-wide linkage...
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