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Article

Two loci on chromosome 15 control experimentally induced arthritis through the differential regulation of IL-6 and lymphocyte proliferation.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2008

Glant Tibor T, Szántó Sándor, Vegvari Aniko, Szabo Zoltan, Kis-Toth Katalin, Mikecz Katalin, Adarichev Vyacheslav A

Abstract excerpt

Using genetic linkage analysis of proteoglycan-induced arthritis (PGIA), a murine model for rheumatoid arthritis, we identified two loci, Pgia8 and Pgia9, on chromosome 15 (chr15) that appear to be implicated in disease susceptibility. Immunization of congenic strains carrying the entire chr15 and separately each of the two loci of DBA/2 arthritis-resistant origin in susceptible BALB/c background confirmed...

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PMID: 18606685
DOI: 10.4049/jimmunol.181.2.1307

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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