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Article

Two major interacting chromosome loci control disease susceptibility in murine model of spondyloarthropathy.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 2005

Végvári Anikó, Szabó Zoltán, Szántó Sándor, Nesterovitch Andrew B, Mikecz Katalin, Glant Tibor T, Adarichev Vyacheslav A

Abstract excerpt

Autoimmune spondylitis was induced in BALB/c mice and their MHC-matched (BALB/c x DBA/2)F1 and F2 hybrids by systemic immunization with cartilage/intervertebral disk proteoglycan (PG). As in human ankylosing spondylitis, the MHC was the major permissive genetic locus in murine PG-induced spondylitis (PGIS). Two major non-MHC chromosome loci with highly significant linkage were found on chromosomes 2 (Pgis2) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16081819
DOI: 10.4049/jimmunol.175.4.2475

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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