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Article

IL23R mutations associated with decreased risk of psoriasis lead to the differential expression of genes implicated in the disease.

Experimental dermatology - 1 Sept 2024

Rane Shraddha S, Shellard Elan, Adamson Antony, Eyre Steve, Warren Richard B

Abstract excerpt

Psoriasis is an incurable immune-mediated skin disease, affecting around 1%-3% of the population. Various lines of evidence implicate IL23 as being pivotal in disease. Genetic variants within the IL23 receptor (IL23R) increase the risk of developing psoriasis, and biologic therapies specifically targeting IL23 demonstrated high efficacy in treating disease. IL23 acts via the IL23R, signalling through the STAT3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39306854
DOI: 10.1111/exd.15180

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