Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Paclitaxel Binding to Human and Murine MD-2

24 Jul 2008

Abstract excerpt

Paclitaxel (PTX) is an important cancer chemotherapeutic agent that binds to beta-tubulin and prevents mitosis through microtubule overstabilization. Recent evidence also implicates PTX in the induction of apoptosis of cancer cells via the TLR4 innate immune pathway. The TLR4 accessory protein, MD-2, is an essential component for the species-specific proinflammatory activity of PTX on murine cells. However,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Transport and Resistance Mechanisms
Share to Immune Response and Inflammation
Share to NF-κB Signaling Pathways

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18650420
DOI: 10.1074/jbc.m802826200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Paclitaxel Binding to Human and Murine MD-2PMID 18650420Read ↗

Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect.Semantic proximity Read ↗

Mutational analysis of membrane and soluble forms of human MD-2.Semantic proximity Read ↗

The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1.Semantic proximity Read ↗

TPA induction of EL4 resistance to macrophage-released TNF: role of ADP-ribosylation in tumoricidal activities of TNF and other factors.Semantic proximity Read ↗

Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2.Semantic proximity Read ↗

Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2.Semantic proximity Read ↗

The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol.Semantic proximity Read ↗

IL2-PE664Glu, a new chimeric protein cytotoxic to human-activated T lymphocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.