Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect.

The Journal of biological chemistry - 22 May 2009

E Shuyu, Lai Yun-Ju, Tsukahara Ryoko, Chen Chen-Shan, Fujiwara Yuko, Yue Junming, Yu Jei-Hwa, Guo Huazhang, Kihara Akio, Tigyi Gábor, Lin Fang-Tsyr

Abstract excerpt

The G protein-coupled lysophosphatidic acid 2 (LPA(2)) receptor elicits prosurvival responses to prevent and rescue cells from apoptosis. However, G protein-coupled signals are not sufficient for the full protective effect of LPA(2). LPA(2) differs from other LPA receptor subtypes in the C-terminal tail, where it contains a zinc finger-binding motif for the interactions with LIM domain-containing TRIP6 and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATPases Associated with Diverse Cellular Activities
Share to Calcium Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoprotection

Share to Doxorubicin

Share to LIM Domain Proteins

Share to Lipoylation

Share to Lysophospholipids

Share to Sodium-Hydrogen Exchangers

Source

Open in PubMed Open full text

Identifiers

PMID: 19293149
DOI: 10.1074/jbc.M900185200
PMCID: PMC2682904

Genes

LPA
TRIP6
NHERF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect.PMID 19293149Read ↗

Lysophosphatidic Acid Signaling and microRNAs: New Roles in Various CancersSemantic proximity Read ↗

TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.Semantic proximity Read ↗

AGE-RAGE synergy influences programmed cell death signaling to promote cancerSemantic proximity Read ↗

Ehrlichia SLiM ligand mimetic activates Hedgehog signaling to engage a BCL-2 anti-apoptotic cellular programSemantic proximity Read ↗

PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.Semantic proximity Read ↗

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response.Semantic proximity Read ↗

Lysophosphatidic acid receptors in cancer pathobiology.Semantic proximity Read ↗

Paclitaxel Binding to Human and Murine MD-2Semantic proximity Read ↗

Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform.Semantic proximity Read ↗

Diverse effects of LPA receptors on cell motile activities of cancer cellsSemantic proximity Read ↗

Rational design of heterodimeric receptors capable of activating target signaling molecules.Semantic proximity Read ↗

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.