Article
IL2-PE664Glu, a new chimeric protein cytotoxic to human-activated T lymphocytes.
The Journal of biological chemistry - 25 Sept 1990
Lorberboum-Galski H, Garsia R J, Gately M, Brown P S, Clark R E, Waldmann T A, Chaudhary V K, FitzGerald D J, Pastan I
Abstract excerpt
To produce a molecule that will kill activated T cells as well as lymphomas and leukemias expressing interleukin 2 (IL2) receptors, we have created a recombinant chimeric protein in which IL2 is attached in peptide linkage to a truncated mutant form of Pseudomonas exotoxin (PE) (Lorberboum-Galski, H., FitzGerald, D.J.P., Chandhary, V.K., Adhya, S., and Pastan, I. (1988) Proc. Natl. Acad. Sci. U.S.A. 85,...
Topics
- ADP Ribose Transferases
- Animals
- Bacterial Toxins
- Base Sequence
- Cell Line
- Cell Survival
- Chimera
- Exotoxins
- Glutamates
- Glutamic Acid
- Humans