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Article

Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2.

Proceedings of the National Academy of Sciences of the United States of America - 10 Aug 2021

Liu Heng, Deepak R N V Krishna, Shiriaeva Anna, Gati Cornelius, Batyuk Alexander, Hu Hao, Weierstall Uwe, Liu Wei, Wang Lei, Cherezov Vadim, Fan Hao, Zhang Cheng

Abstract excerpt

Prostaglandin D2 (PGD2) signals through the G protein-coupled receptor (GPCR) CRTH2 to mediate various inflammatory responses. CRTH2 is the only member of the prostanoid receptor family that is phylogenetically distant from others, implying a nonconserved mechanism of lipid action on CRTH2. Here, we report a crystal structure of human CRTH2 bound to a PGD2 derivative, 15R-methyl-PGD2 (15mPGD2), by serial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34341104
DOI: 10.1073/pnas.2102813118
PMCID: PMC8364189

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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