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Article

Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2.

The Journal of biological chemistry - 16 Sept 2005

Hata Aaron N, Lybrand Terry P, Breyer Richard M

Abstract excerpt

The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a G protein-coupled receptor that mediates the pro-inflammatory effects of prostaglandin D(2) (PGD(2)) generated in allergic inflammation. The CRTH2 receptor shares greatest sequence similarity with chemoattractant receptors compared with prostanoid receptors. To investigate the structural determinants of CRTH2 ligand binding, we...

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Identifiers

PMID: 16030019
DOI: 10.1074/jbc.M502563200

Genes

PGD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2.PMID 16030019Read ↗

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