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HMGB1: An overview of its roles in the pathogenesis of liver disease

30 Mar 2021

Abstract excerpt

High-mobility group box 1 (HMGB1) is an abundant architectural chromosomal protein that has multiple biologic functions: gene transcription, DNA replication, DNA-damage repair, and cell signaling for inflammation. HMGB1 can be released passively by necrotic cells or secreted actively by activated immune cells into the extracellular milieu after injury. Extracellular HMGB1 acts as a damage-associated molecular...

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PMID: 33784425
DOI: 10.1002/jlb.3mr0121-277r

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