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Multiple functions of HMGB1 in cancer

25 Apr 2024

Abstract excerpt

High mobility group box 1 (HMGB1) is a nuclear DNA-binding protein with a dual role in cancer, acting as an oncogene and a tumor suppressor. This protein regulates nucleosomal structure, DNA damage repair, and genomic stability within the cell, while also playing a role in immune cell functions. This review comprehensively evaluates the biological and clinical significance of HMGB1 in cancer, including its...

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PMID: 38725632
DOI: 10.3389/fonc.2024.1384109

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