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Article

Evidence for Involvement of HMGB1 Protein in Human DNA Mismatch Repair

1 May 2004

Abstract excerpt

Defects in human DNA mismatch repair predispose to cancer, but many components of the pathway have not been identified. We report here the identification and characterization of a novel component required for mismatch repair in human cells. A 30-kDa protein was purified to homogeneity by virtue of its ability to complement a depleted HeLa extract in repair of mismatched heteroduplexes. The complementing activity...

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Identifiers

PMID: 15014079
DOI: 10.1074/jbc.m401931200

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