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Article

HMGB1-mediated DNA bending: Distinct roles in increasing p53 binding to DNA and the transactivation of p53-responsive gene promoters.

Biochimica et biophysica acta. Gene regulatory mechanisms - 1 Mar 2018

Štros Michal, Kučírek Martin, Sani Soodabeh Abbasi, Polanská Eva

Abstract excerpt

HMGB1 is a chromatin-associated protein that has been implicated in many important biological processes such as transcription, recombination, DNA repair, and genome stability. These functions include the enhancement of binding of a number of transcription factors, including the tumor suppressor protein p53, to their specific DNA-binding sites. HMGB1 is composed of two highly conserved HMG boxes, linked to an...

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Source

Identifiers

PMID: 29421308
DOI: 10.1016/j.bbagrm.2018.02.002

Genes

HMGB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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