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Article

Induction of protective immunity by vaccination with wild-type apo superoxide dismutase 1 in mutant SOD1 transgenic mice.

Journal of neuropathology and experimental neurology - 1 Oct 2010

Takeuchi Shigeko, Fujiwara Noriko, Ido Akemi, Oono Miki, Takeuchi Yuki, Tateno Minako, Suzuki Keiichiro, Takahashi Ryosuke, Tooyama Ikuo, Taniguchi Naoyuki, Julien Jean-Pierre, Urushitani Makoto

Abstract excerpt

Vaccinations targeting extracellular superoxide dismutase 1 (SOD1) mutants are beneficial in mouse models of amyotrophic lateral sclerosis (ALS). Because of its misfolded nature, wild-type nonmetallated SOD1 protein (WT-apo) may have therapeutic application for vaccination of various SOD1 mutants. We compared the effects of WT-apo to those of a G93A SOD1 vaccine in low-copy G93A SOD1 transgenic mice. Both SOD1...

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Identifiers

PMID: 20838241
DOI: 10.1097/NEN.0b013e3181f4a90a

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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