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Allogeneic B cell immunomodulatory therapy in amyotrophic lateral sclerosis

5 Jul 2024

Abstract excerpt

Abstract Amyotrophic lateral sclerosis (ALS) is an orphan neurodegenerative disease. Immune system dysregulation plays an essential role in ALS onset and progression. Our preclinical studies have shown that the administration of exogenous allogeneic B cells improves outcomes in murine models of skin and brain injury through a process termed pligodraxis, in which B cells adopt an immunoregulatory and...

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PMID: 38967302
DOI: 10.1096/fj.202302659r

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