Article
Clonally expanded CD8 T cells characterize amyotrophic lateral sclerosis-4.
Nature - 1 Jun 2022
Campisi Laura, Chizari Shahab, Ho Jessica S Y, Gromova Anastasia, Arnold Frederick J, Mosca Lorena, Mei Xueyan, Fstkchyan Yesai, Torre Denis, Beharry Cindy, Garcia-Forn Marta, Jiménez-Alcázar Miguel, Korben Vlad A., Prazich Jack, Fayad Zahi A, Seldin Marcus M, De Rubeis Silvia, Bennett Craig L, Ostrow Lyle W, Lunetta Christian, Squatrito Massimo, Byun Minji, Shneider Neil A, Jiang Ning, La Spada Albert R, Marazzi Ivan
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a heterogenous neurodegenerative disorder that affects motor neurons and voluntary muscle control1. ALS heterogeneity includes the age of manifestation, the rate of progression and the anatomical sites of symptom onset. Disease-causing mutations in specific genes have been identified and define different subtypes of ALS1. Although several ALS-associated genes have been shown...
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