Article
Impairment of adolescent hippocampal plasticity in a mouse model for Alzheimer's disease precedes disease phenotype.
PloS one - 23 Jul 2008
Hartl Daniela, Rohe Michael, Mao Lei, Staufenbiel Matthias, Zabel Claus, Klose Joachim
Abstract excerpt
The amyloid precursor protein (APP) was assumed to be an important neuron-morphoregulatory protein and plays a central role in Alzheimer's disease (AD) pathology. In the study presented here, we analyzed the APP-transgenic mouse model APP23 using 2-dimensional gel electrophoresis technology in co...
Topics
- Alzheimer Disease
- Animals
- Cerebral Cortex
- Disease Models, Animal
- Disease Progression
- Electrophoresis, Gel, Two-Dimensional
- GAP-43 Protein
- Gene Expression Regulation
- Hippocampus
- Humans
- Mice
- Neuronal Plasticity