Article
Outstanding Phenotypic Differences in the Profile of Amyloid-β between Tg2576 and APPswe/PS1dE9 Transgenic Mouse Models of Alzheimer's Disease.
Journal of Alzheimer's disease : JAD - 30 May 2016
Allué José Antonio, Sarasa Leticia, Izco María, Pérez-Grijalba Virginia, Fandos Noelia, Pascual-Lucas María, Ogueta Samuel, Pesini Pedro, Sarasa Manuel
Abstract excerpt
APPswe/PS1dE9 and Tg2576 are very common transgenic mouse models of Alzheimer's disease (AD), used in many laboratories as tools to research the mechanistic process leading to the disease. In order to augment our knowledge about the amyloid-β (Aβ) isoforms present in both transgenic mouse models, we have developed two chromatographic methods, one acidic and the other basic, for the characterization of the Aβ...
Topics
- Age Factors
- Alzheimer Disease
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Animals
- Brain
- Chromatography
- Disease Models, Animal
- Female
- Gene Expression Regulation
- Humans
- Immunoprecipitation
- Male