Dynamic Temporal Changes in Urinary Proteome of Pregnant Wild-Type Mice Carrying Heterozygous 3xTg-AD Fetuses

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder with insidious onset. At present, effective early diagnostic biomarkers are scarce, and few studies have explored ultra-early molecular alterations during embryonic development. Urinary proteomics boasts unique strengths including complete non-invasiveness, repeatable sequential sampling and high detection sensitivity, which provides a potential...

Topics

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• Age Factors
• Alzheimer Disease
• Alzheimer's disease research and treatments
• Amyloid beta-Protein Precursor
• Antibodies
• Diagnostic Tests, Routine
• Neuroinflammation and Neurodegeneration Mechanisms
• Nuclear Receptors and Signaling

Identifiers and source

Literature Corpus work

88bd0f64-ab12-51c1-827e-d8d8b6414ff9

DOI

10.64898/2026.07.23.740247