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Article

Cyclin-dependent kinase 5 activator p25 is generated during memory formation and is reduced at an early stage in Alzheimer's disease.

Biological psychiatry - 15 Jul 2011

Engmann Olivia, Hortobágyi Tibor, Thompson Andrew J, Guadagno Jennifer, Troakes Claire, Soriano Salvador, Al-Sarraj Safa, Kim Yong, Giese Karl Peter

Abstract excerpt

BACKGROUND: The cyclin-dependent kinase 5 activator p35 can be cleaved into p25. Formation of p25 has been suggested to contribute to neurodegeneration in Alzheimer's disease (AD). However, overexpression of low levels of p25 in mice enhances memory formation. Therefore, it has been suggested that p25 formation might be an event early in AD to compensate for impairments in synaptic plasticity. Ongoing p25...

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PMID: 21616478
DOI: 10.1016/j.biopsych.2011.04.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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