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Article

Association of protein function-altering variants with cardiometabolic traits: the strong heart study.

Scientific reports - 4 Jun 2022

Shan Yue, Cole Shelley A, Haack Karin, Melton Phillip E, Best Lyle G, Bizon Christopher, Kobes Sayuko, Köroğlu Çiğdem, Baier Leslie J, Hanson Robert L, Sanna Serena, Li Yun, Franceschini Nora

Abstract excerpt

Clinical and biomarker phenotypic associations for carriers of protein function-altering variants may help to elucidate gene function and health effects in populations. We genotyped 1127 Strong Heart Family Study participants for protein function-altering single nucleotide variants (SNV) and indels selected from a low coverage whole exome sequencing of American Indians. We tested the association of each SNV/indel...

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Share to Cardiovascular Diseases
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 35665752
DOI: 10.1038/s41598-022-12866-2
PMCID: PMC9167281

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