Article
Multifunctional human CD56 low CD16 low natural killer cells are the prominent subset in bone marrow of both healthy pediatric donors and leukemic patients.
Haematologica - 1 Apr 2015
Stabile Helena, Nisti Paolo, Morrone Stefania, Pagliara Daria, Bertaina Alice, Locatelli Franco, Santoni Angela, Gismondi Angela
Abstract excerpt
We phenotypically and functionally characterized a distinct CD56(low) natural killer cell subset based on CD16 expression levels in bone marrow and peripheral blood of healthy children and pediatric patients with acute lymphoblastic leukemia. Our findings demonstrate for the first time that CD56(low)CD16(low) natural killer cells are more abundant in bone marrow than in peripheral blood and that their frequency...
Topics
- Adult
- Age Factors
- Bone Marrow Cells
- CD56 Antigen
- Case-Control Studies
- Cell Degranulation
- Chemokines
- Child
- Child, Preschool
- Cytotoxicity, Immunologic
- Humans
- Immunophenotyping
- Interferons