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CD56brightCD16+ NK Cells: A Functional Intermediate Stage of NK Cell Differentiation

10 May 2011

Abstract excerpt

Human NK cells comprise two main subsets, CD56(bright) and CD56(dim) cells, which differ in function, phenotype, and tissue localization. To further dissect the differentiation from CD56(bright) to CD56(dim) cells, we performed ex vivo and in vitro experiments demonstrating that the CD56(bright)CD16(+) cells are an intermediate stage of NK cell maturation. We observed that the maximal frequency of the...

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PMID: 21555534
DOI: 10.4049/jimmunol.1100330

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