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Article

Lipoproteins of Listeria monocytogenes are critical for virulence and TLR2-mediated immune activation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2008

Machata Silke, Tchatalbachev Svetlin, Mohamed Walid, Jänsch Lothar, Hain Torsten, Chakraborty Trinad

Abstract excerpt

Numerous cell surface components of Listeria influence and regulate innate immune recognition and virulence. Here, we demonstrate that lipidation of prelipoproteins in Listeria monocytogenes is required to promote NF-kappaB activation via TLR2. In HeLa cells transiently expressing TLR2, L. monocytogenes and Listeria innocua mutants lacking the prolipoprotein diacylglyceryl transferase (lgt) gene are unable to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18641340
DOI: 10.4049/jimmunol.181.3.2028

Genes

TLR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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