Article
Both TLR2 and TRIF contribute to interferon-β production during Listeria infection.
PloS one - 1 Jan 2012
Aubry Camille, Corr Sinéad C, Wienerroither Sebastian, Goulard Céline, Jones Ruth, Jamieson Amanda M, Decker Thomas, O'Neill Luke A J, Dussurget Olivier, Cossart Pascale
Abstract excerpt
Synthesis of interferon-β (IFN-β) is an innate response to cytoplasmic infection with bacterial pathogens. Our recent studies showed that Listeria monocytogenes limits immune detection and IFN-β synthesis via deacetylation of its peptidoglycan, which renders the bacterium resistant to lysozyme degradation. Here, we examined signaling requirements for the massive IFN-β production resulting from the infection of...
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