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Article

Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.

The Journal of biological chemistry - 24 Dec 2004

Zamboni Dario S, Campos Marco A, Torrecilhas Ana C T, Kiss Kati, Samuel James E, Golenbock Douglas T, Lauw Fanny N, Roy Craig R, Almeida Igor C, Gazzinelli Ricardo T

Abstract excerpt

Innate and adaptive immune responses are initiated upon recognition of microbial molecules by Toll-like receptors (TLRs). We have investigated the importance of these receptors in the induction of pro-inflammatory cytokines and macrophage resistance to infection with Coxiella burnetii, an obligate intracellular bacterium and the etiological agent of Q fever. By using a Chinese hamster ovary/CD14 cell line...

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Source

Identifiers

PMID: 15485838
DOI: 10.1074/jbc.M410340200

Genes

TLR2
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.PMID 15485838Read ↗

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