Article

Mycobacterium tuberculosis canonical virulence factors interfere with a late component of the TLR2 response.

2021-10-06

Abstract excerpt

For many intracellular pathogens, the phagosome is the site of events and interactions that shape infection outcome. Phagosomal membrane damage, in particular, is proposed to benefit invading pathogens. To define the innate immune consequences of this damage, we profiled macrophage transcriptional responses to wild-type Mycobacterium tuberculosis (Mtb) and mutants that fail to damage the phagosomal membrane. We id...

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Literature Corpus work: 9d85e5a2-6f38-5552-9eb8-7cff12794adb
DOI: 10.1101/2021.10.06.463251

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