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Article

MyD88-dependent but Toll-like receptor 2-independent innate immunity to Listeria: no role for either in macrophage listericidal activity.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2002

Edelson Brian T, Unanue Emil R

Abstract excerpt

We have assessed the requirements for Toll-like receptor (TLR) signaling in vivo during early infection with Listeria monocytogenes. Mice deficient for TLR2, a receptor required for the recognition of Gram-positive peptidoglycan, showed equivalent Listeria resistance to wild-type mice. However, mice deficient for MyD88, an adaptor molecule used by all TLRs, showed profound susceptibility with 3-4 logs greater...

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Share to Listeria monocytogenes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myeloid Differentiation Factor 88

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Source

Identifiers

PMID: 12244184
DOI: 10.4049/jimmunol.169.7.3869

Genes

TLR2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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