Article
Inactivation of Lgt allows systematic characterization of lipoproteins from Listeria monocytogenes.
Journal of bacteriology - 1 Jan 2007
Baumgärtner Maja, Kärst Uwe, Gerstel Birgit, Loessner Martin, Wehland Jürgen, Jänsch Lothar
Abstract excerpt
Lipoprotein anchoring in bacteria is mediated by the prolipoprotein diacylglyceryl transferase (Lgt), which catalyzes the transfer of a diacylglyceryl moiety to the prospective N-terminal cysteine of the mature lipoprotein. Deletion of the lgt gene in the gram-positive pathogen Listeria monocytogenes (i) impairs intracellular growth of the bacterium in different eukaryotic cell lines and (ii) leads to increased...
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