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Article

Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.

Immunity - 24 Jun 2011

Dudeck Anne, Dudeck Jan, Scholten Julia, Petzold Anke, Surianarayanan Sangeetha, Köhler Anja, Peschke Katrin, Vöhringer David, Waskow Claudia, Krieg Thomas, Müller Werner, Waisman Ari, Hartmann Karin, Gunzer Matthias, Roers Axel

Abstract excerpt

A prominent feature of sensitizing environmental compounds that cause allergic contact dermatitis is the rapid induction of an innate inflammatory response that seems to provide danger signals for efficient T cell priming. We generated mouse models of mast cell deficiency, mast cell-specific gene inactivation, and mast cell reporter mice for intravital imaging and showed that these adjuvant effects of contact...

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Share to Adjuvants, Immunologic
Share to Dermatitis, Allergic Contact

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21703544
DOI: 10.1016/j.immuni.2011.03.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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