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Article

Phenotypic alteration of eukaryotic cells using randomized libraries of artificial transcription factors.

Nature biotechnology - 1 Oct 2003

Park Kyung-Soon, Lee Dong-ki, Lee Horim, Lee Yangsoon, Jang Young-Soon, Kim Yong Ha, Yang Hyo-Young, Lee Seong-il, Seol Wongi, Kim Jin-Soo, Lee Sung-Il

Abstract excerpt

We have developed a method in which randomized libraries of zinc finger-containing artificial transcription factors are used to induce phenotypic variations in yeast and mammalian cells. By linking multiple zinc-finger domains together, we constructed more than 100,000 zinc-finger proteins with d...

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PMID: 12960965
DOI: 10.1038/nbt868

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12960965-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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