Leishmania : Responding to environmental signals and challenges without regulated transcription

Abstract excerpt

Here we describe the non-canonical control of gene expression in Leishmania , a single-cell parasite that is responsible for one of the major neglected tropical diseases. We discuss the lack of regulated RNA synthesis, the post-transcriptional gene regulation including RNA stability and regulated translation. We also show that genetic adaptations such as mosaic aneuploidy, gene copy number variations and DNA...

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