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Article

Drug resistance analysis by next generation sequencing in Leishmania.

International journal for parasitology. Drugs and drug resistance - 1 Apr 2015

Leprohon Philippe, Fernandez-Prada Christopher, Gazanion Élodie, Monte-Neto Rubens, Ouellette Marc

Abstract excerpt

The use of next generation sequencing has the power to expedite the identification of drug resistance determinants and biomarkers and was applied successfully to drug resistance studies in Leishmania. This allowed the identification of modulation in gene expression, gene dosage alterations, changes in chromosome copy numbers and single nucleotide polymorphisms that correlated with resistance in Leishmania strains...

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Identifiers

PMID: 25941624
DOI: 10.1016/j.ijpddr.2014.09.005
PMCID: PMC4412915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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