Article
Evidence against PALB2 involvement in Icelandic breast cancer susceptibility.
Journal of negative results in biomedicine - 17 Jul 2008
Gunnarsson Haukur, Arason Adalgeir, Gillanders Elizabeth M, Agnarsson Bjarni A, Johannesdottir Gudrun, Johannsson Oskar Th, Barkardottir Rosa B
Abstract excerpt
Several mutations in the PALB2 gene (partner and localizer of BRCA2) have been associated with an increased risk of breast cancer, including a founder mutation, 1592delT, reported in Finnish breast cancer families. Although most often the risk is moderate, it doesn't exclude families with high-risk mutations to exist and such observations have been reported. To see if high-risk PALB2-mutations may be present in...
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