Article
A recurrent mutation in PALB2 in Finnish cancer families.
Nature - 15 Mar 2007
Erkko Hannele, Xia Bing, Nikkilä Jenni, Schleutker Johanna, Syrjäkoski Kirsi, Mannermaa Arto, Kallioniemi Anne, Pylkäs Katri, Karppinen Sanna-Maria, Rapakko Katrin, Miron Alexander, Sheng Qing, Li Guilan, Mattila Henna, Bell Daphne W, Haber Daniel A, Grip Mervi, Reiman Mervi, Jukkola-Vuorinen Arja, Mustonen Aki, Kere Juha, Aaltonen Lauri A, Kosma Veli-Matti, Kataja Vesa, Soini Ylermi, Drapkin Ronny I, Livingston David M, Winqvist Robert
Abstract excerpt
BRCA1, BRCA2 and other known susceptibility genes account for less than half of the detectable hereditary predisposition to breast cancer. Other relevant genes therefore remain to be discovered. Recently a new BRCA2-binding protein, PALB2, was identified. The BRCA2-PALB2 interaction is crucial for certain key BRCA2 DNA damage response functions as well as its tumour suppression activity. Here we show, by...
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